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Materials Science at Oregon State University

Amperometric and Field Effect Sensing of Glucose

Date: Thursday, Apr 28th
Presenter: Prof. Greg Herman, OSU Materials Science and Chemical Engineering


Type 1 diabetes is a pancreatic disease where individuals are not able to produce insulin to control blood glucose levels. For individuals with type 1 diabetes a promising approach to control blood sugar is with an artificial endocrine pancreas, which continuously reads blood glucose concentrations and automatically controls insulin and glucagon injections. In this presentation, we will discuss the digital fabrication of a novel flexible amperometric glucose sensor and the development of a transparent field effect glucose sensor. First, we will discuss the digital fabrication of the amperometric glucose sensor. For this sensor, we are evaluating additive manufacturing approaches, including electrohydrodynamic (e-jet) printing and electroplating, for rapid optimization of the sensor, improved uniformity, and ultimately reductions in manufacturing costs. The sensor is fabricated on flexible substrates and can be mounted directly on catheters which will be used to deliver insulin and glucagon. Next, we will discuss the development of a novel field effect glucose sensor. For these studies we are using In-Ga-Zn-O (a-IGZO) as a transducer for sensing, where selectivity to glucose was performed by functionalizing the a-IGZO surface with glucose oxidase. Significant changes in the electronic properties were observed due to depletion/accumulation of carriers in the a-IGZO upon reaction of glucose with glucose oxidase. These results provide insight into a route to develop low-cost transparent biochemical sensors based on a-IGZO.

GREGORY S. HERMAN is a Professor in the School of Chemical, Biological and Environmental Engineering at Oregon State University (OSU). Prior to joining OSU, he was a senior scientist at Sharp Laboratories of America, a research and development engineer at Hewlett-Packard, and a senior research scientist at Pacific Northwest National Laboratory. He received his B.S. degree in Chemistry (University of Wisconsin-Parkside) and his PhD in Physical Chemistry (University of Hawaii at Manoa). The primary focus of Gregory’s research is to obtain fundamental understanding of structural/compositional/functional relationships of electronic, optoelectronic, and catalytic materials. He has published over 100 peer-reviewed scientific publications and has over 65 patents.