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Materials Science at Oregon State University

External field stimulation for enhanced cell proliferation and bactericidal property on engineered biomaterials: Analytical modeling and experimental approaches - PLEASE NOTE - Seminar is on MONDAY April 15 at 5pm

Date: Monday, Apr 15th
Presenter: Bikramjit Basu, Laboratory for Biomaterials, Materials Research Center, Indian Institute of Science, Bangalore, India

Abstract


In the interdisciplinary field of biomaterials, the phenomenological interaction of a biological cell on a material substrate under normal culture conditions is broadly known and researchers use many approaches to tailor surface modulus or surface wettability in an effort to enhance cell-material interaction. In this context, a strikingly different approach will be presented in this talk. It will be shown how the intermittent delivery of pulse electric field stimulation can enhance cell growth on electroconductive biomaterial substrates, which are fabricated using a novel processing route (Spark Plasma Sintering). The effectiveness of the above approach will be demonstrated using multiple cell lines (bone cells, neuronal cells, muscle cells, gram positive and gram negative bacteria) as well as on materials with varying stiffness and conductivity properties. This novel approach overcomes the conventional biological approach of various biochemical growth factor additions to enhance cell growth/differentiation in vitro.
Starting from deterministic modeling to solve a structurally detailed electrical analog of a single cell [J. Applied Physics (2009)], the inherent randomness of the biological system of multiple cells in culture into the cell-external field interaction will be introduced using the stochastic modeling approach [J.Biological Physics (2011)]. The results of the analytical studies provide an estimate of the time of cell interaction as well as the critical window of the current fluctuation for a stimulated biological cell. Extending simulation work to experimental research, a narrow window of electric field stimulation parameters will be shown to facilitate optimal cell growth on biomaterial substrates [J. Biomedical Materials Research (2011)]. Also, the results obtained with biomaterials having a range of electrical conductivity will be presented to demonstrate the synergistic role of the external field stimulation and substrate conductivity towards the modulation of in vitro cell fate processes (proliferation, differentiation). Extending the approach of electrical stimulation, subsequent research has demonstrated the effect of weak magnetic field towards bactericidal effect in vitro. The recent results will illustrate how to tailor the maximum bactericidal effect without compromising the cell compatibility property with the application of magnetic field stimulation on magnetic biocomposites.

Biography:
Dr. Bikramjit Basu is an Associate Professor at Materials Research Center, Indian Institute of Science (IISc), Bangalore since May, 2011. As an Associate Faculty of Bio-Engineering programme, he is currently taking a pivotal role in shaping the academic and research components of this new program at IISc. Born on September 15, 1973, he obtained his undergraduate and postgraduate degrees, both in Metallurgical Engineering, from National Institute of Technology (NIT), Durgapur and IISc in 1995 and 1997, respectively. He earned his PhD in Ceramics at Katholieke Universiteit Leuven, Belgium in March, 2001. After a brief stint at University of California (UCSB) as a post-doctoral researcher, he joined IIT Kanpur (IIT K) in November 2001 as Assistant Professor and rose to the position of Full Professor in March, 2011.
In India, Dr. Basu has established a vibrant research program on structural ceramics and functional biomaterials. He has authored/co-authored 192 peer-reviewed research papers with twenty papers in Journal of American Ceramic Society. H-index of his publications is 24 and a total citation is 1990 with 300 plus citations per year over last four years (388 citations in 2012, as per www.scopus.com). He edited a book on Biomaterials (2008) and authored two textbooks as first author in each case - one on Structural Ceramics (2011) and the other on Tribology (2011), all published by John Wiley and Sons, Inc. He is currently on editorial board of 12 SCI journals and the Editor of the Journal of Asian Ceramic Societies.
In last one decade, Dr. Basu’s research largely focuses to bridge the gap between Materials Science and Biological Sciences to develop new biomaterials as well as to emerge with a comprehensive understanding of cell-material interactions at various length scales. Dr. Basu also led major international multi-institutional research program on biomaterials. As Principal Investigator of Indo-US science and Technology forum funded Biomaterials Center (2008-2012) as well as UK-India Education and Research Initiative (2009-2012), he has led multiple bilateral projects in the area of orthopaedics and cardiovascular tissue engineering. In order to promote research and education aspects in the field of Biomaterials, Dr. Basu started BIND- conference series (IIT K in 2006 and IISc in 2012) and BIOMAT-workshop series (IIT K in 2007 and IISc in 2012) and organized several sessions in International conferences.
In recognition of contributions to the field of Ceramic Science and Biomaterials Science, Dr. Basu received noteworthy awards from the Indian Ceramic Society (2003), Indian National Academy of Engineering (2004), Indian National Science Academy (2005), ‘Metallurgist of the year’ award (2010) by Ministry of Steels, Government of India, ‘NASI - SCOPUS Young Scientist Award’, 2010 by Elsevier partnered with the National Academy of Sciences, India (NASI) and lately, Materials Research Society of India (MRSI) Medal, 2011. He is the first and only Indian from India, till todate, to receive the prestigious ‘Coble Award for Young Scholars’ (highest recognition for any young ceramicist of age 35 or below) from the American Ceramic Society in 2008. Many of his former students are currently serving as faculty members in various IITs/NIT and have gone on to receive national awards from Government of India. In addition to his scholarly contributions, he delivered more than 100 invited seminars abroad and is known to the peers in Europe, USA and Japan.